Jorge Zepeda Patterson has an interesting column on AMLO's possible battles with fatigue here. Zepeda dings AMLO for his swing to the center toward the end, and I think you can make a good case that his conspicuous moderation of the past few weeks was ill planned. At the same time, I can't think of a way that doubling down on his past approach to politics would have brought better results. Ultimately, it's like finding tactical reasons that your local college team couldn't beat the Giants. Also, the only suggestions Zepeda really offers are more strategy and more delegation to his subordinates, which is too vague to be helpful.
Aguachile also discusses the matter here.