The organization is now in the hands of El Coss, Eduardo Costilla, and Mario Cárdenas Guillén, Tony and Osiel's brother. Although my understanding is that Costilla didn't really ascend as a result of last week's killing; he already was a major leader.
Also, there is speculation that this is good news for the Zetas, which it probably is, though it's always very difficult to predict the exact ramifications of any episode in an industry where everyone hides their activities.
Marine high-ups are saying that they were on Ezequiel Cárdenas' trail for six months, which is a lot like what they said after they killed Arturo Beltrán Leyva. One wonders if it's all talk, or if they are just a lot better at doing the painstaking tracking that works against the capos. If so, that institutional knowledge should be exported.